Justa S, Minz R W, Minz M, Sharma A, Anand S, Das A, Chawla Y K, Sakhuja V K
Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Transplant Proc. 2010 Nov;42(9):3568-73. doi: 10.1016/j.transproceed.2010.07.102.
There is a high prevalence of hepatitis C virus (HCV) infection among immunosuppressed patients including renal transplant recipients. The study investigated serum viral loads for up to 6 months posttransplantation among these patients. Serum viral load was serially monitored using real-time polymerase chain reaction (PCR) in 25 HCV-positive renal transplant recipients pretransplantation as well as day 10 and 6 months posttransplantation. A liver biopsy specimen obtained under vision at the time of transplantation was analyzed for viral load as well as for histological changes. There was increased viremia at day 10 followed by a significant (2 log) reduction at 6 months posttransplantation. Pretransplantation serum and intrahepatic viral load showed significant positive correlations (r = 0.727; P = .001), the latter also reflecting liver fibrosis score (r = 0.423; P = .05). The findings suggested that serum viral load reflects intrahepatic viral load, which in turn correlates with liver fibrosis. At 6 months posttransplantation, the modulatory effects of immunosuppressive drugs and of the host immune response may lead to a reduced viral load.
在包括肾移植受者在内的免疫抑制患者中，丙型肝炎病毒（HCV）感染的患病率很高。该研究调查了这些患者移植后长达6个月的血清病毒载量。在25例移植前以及移植后第10天和6个月的HCV阳性肾移植受者中，使用实时聚合酶链反应（PCR）对血清病毒载量进行连续监测。对移植时在直视下获取的肝活检标本进行病毒载量以及组织学变化分析。移植后第10天病毒血症增加，随后在移植后6个月显著（2个对数）降低。移植前血清和肝内病毒载量呈显著正相关（r = 0.727；P = .001），后者也反映肝纤维化评分（r = 0.423；P = .05）。这些发现表明血清病毒载量反映肝内病毒载量，而肝内病毒载量又与肝纤维化相关。在移植后6个月，免疫抑制药物和宿主免疫反应的调节作用可能导致病毒载量降低。
