Aljitawi O S, Rodriguez L, Madan R, Ganguly S, Abhyankar S, McGuirk J P
Division of Hematology, Blood and Marrow Transplantation, University of Kansas Medical Center, Kansas City, Kansas, USA.
Transplant Proc. 2010 Nov;42(9):3892-3. doi: 10.1016/j.transproceed.2010.08.025.
Intestinal perforation in the setting of posttransplantation microangiopathy (TMA) is a very rare event and might be considered a terminal event of intestinal microangiopathy (i-TMA), a rather rarely recognized posttransplantation complication, as it overlaps with the more common intestinal graft-versus-host disease (GVHD). Cases of i-TMA described in literature occurred within with first 100 days posttransplantation or shortly thereafter. In this report, we describe a case of late-onset intestinal perforation that occurred in the setting of systemic microangiopathy more than a year after allogeneic transplantation. In our case, the patient poorly responded to treatment secondary to refractory mircoangiopathy.
移植后微血管病（TMA）背景下的肠穿孔是一种非常罕见的事件，可能被视为肠道微血管病（i-TMA）的终末期事件，i-TMA是一种较少被认识的移植后并发症，因为它与更常见的肠道移植物抗宿主病（GVHD）有重叠。文献中描述的i-TMA病例发生在移植后的前100天内或此后不久。在本报告中，我们描述了一例在异基因移植一年多后发生的系统性微血管病背景下的迟发性肠穿孔病例。在我们的病例中，患者因难治性微血管病对治疗反应不佳。
