Prochaska L, Vacek J, Madan R, Abhyankar S, Ganguly S, McGuirk J P, Lin T L, Aljitawi O S
Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Cardiology and Cardiovascular Research, Mid America Cardiology, University of Kansas Medical Center, Kansas City, Kansas.
Transplant Proc. 2014 Jun;46(5):1536-9. doi: 10.1016/j.transproceed.2013.12.066.
Gastrointestinal ischemia after allogeneic bone marrow transplantation is a rare complication not well-described in the literature. Herein we retrospectively review charts of four patients who developed intestinal ischemia after allogeneic bone marrow transplantation at our institution. The patients were found to be predominately younger males who presented with nonspecific abdominal pain. Graft-versus-host disease was a common finding among all patients. Laboratory values suggestive of microangiopathy were present in two patients. Obesity and hypertriglyceridemia were cardiovascular risk factors found in these patients. The development of thrombotic microangiopathy and cardiovascular risk factors after allogeneic bone marrow transplantation may predispose patients to gastrointestinal ischemia and may portend a poor prognosis.
异基因骨髓移植后发生的胃肠道缺血是一种罕见的并发症，文献中对此描述不多。在此，我们回顾性分析了我院4例异基因骨髓移植后发生肠道缺血患者的病历。这些患者以年轻男性为主，表现为非特异性腹痛。移植物抗宿主病在所有患者中均很常见。两名患者出现提示微血管病的实验室检查结果。肥胖和高甘油三酯血症是这些患者中发现的心血管危险因素。异基因骨髓移植后血栓性微血管病和心血管危险因素的出现可能使患者易患胃肠道缺血，并可能预示预后不良。
