“大产科综合征”与深部胎盘功能障碍有关。
The "Great Obstetrical Syndromes" are associated with disorders of deep placentation.
机构信息
Leuven Institute for Fertility and Embryology, Leuven, Belgium.
出版信息
Am J Obstet Gynecol. 2011 Mar;204(3):193-201. doi: 10.1016/j.ajog.2010.08.009. Epub 2010 Nov 20.
Abstract
Defective deep placentation has been associated with a spectrum of complications of pregnancy including preeclampsia, intrauterine growth restriction, preterm labor, preterm premature rupture of membranes, late spontaneous abortion, and abruptio placentae. The disease of the placental vascular bed that underpins these complications is commonly investigated with targeted biopsies. In this review, we critically evaluate the biopsy technique to summarize the salient types of defective deep placentation, and propose criteria for the classification of defective deep placentation into 3 types based on the degree of restriction of remodeling and the presence of obstructive lesions in the myometrial segment of the spiral arteries.
摘要
胎盘深部植入缺陷与一系列妊娠并发症相关，包括子痫前期、宫内生长受限、早产、胎膜早破早产、晚期自然流产和胎盘早剥。这些并发症所对应的胎盘血管床疾病通常通过靶向活检进行研究。在这篇综述中，我们批判性地评估了活检技术，总结了胎盘深部植入缺陷的主要类型，并基于螺旋动脉肌壁段重塑受限的程度和阻塞性病变的存在，提出了将胎盘深部植入缺陷分为 3 型的分类标准。
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本文引用的文献
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A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia.母体血浆中 sVEGFR-2 浓度的降低先于子痫前期的临床诊断。
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An imbalance between angiogenic and anti-angiogenic factors precedes fetal death in a subset of patients: results of a longitudinal study.在一部分患者中，血管生成因子与抗血管生成因子之间的失衡先于胎儿死亡：一项纵向研究的结果。
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Fetal death: a condition with a dissociation in the concentrations of soluble vascular endothelial growth factor receptor-2 between the maternal and fetal compartments.胎儿死亡：一种母体和胎儿体内可溶性血管内皮生长因子受体-2浓度存在分离的情况。
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Serum and plasma determination of angiogenic and anti-angiogenic factors yield different results: the need for standardization in clinical practice.血清和血浆中血管生成因子及抗血管生成因子的测定结果不同：临床实践中需要标准化。
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