Ecole Normale Supérieure of Lyon, Physics Laboratory CNRS UMR 5672, Lyon, France.
Am J Infect Control. 2011 May;39(4):314-20. doi: 10.1016/j.ajic.2010.06.013. Epub 2010 Nov 20.
Evidence has recently emerged indicating that in addition to large airborne droplets, fine aerosol particles can be an important mode of influenza transmission that may have been hitherto underestimated. Furthermore, recent performance studies evaluating airborne infection isolation (AII) rooms designed to house infectious patients have revealed major discrepancies between what is prescribed and what is actually measured.
We conducted an experimental study to investigate the use of high-throughput in-room air decontamination units for supplemental protection against airborne contamination in areas that host infectious patients. The study included both intrinsic performance tests of the air-decontamination unit against biological aerosols of particular epidemiologic interest and field tests in a hospital AII room under different ventilation scenarios.
The unit tested efficiently eradicated airborne H5N2 influenza and Mycobacterium bovis (a 4- to 5-log single-pass reduction) and, when implemented with a room extractor, reduced the peak contamination levels by a factor of 5, with decontamination rates at least 33% faster than those achieved with the extractor alone.
High-throughput in-room air treatment units can provide supplemental control of airborne pathogen levels in patient isolation rooms.
最近有证据表明，除了大飞沫外，细小的气溶胶颗粒也可能是流感传播的一种重要方式，而这一点此前可能被低估了。此外，最近对评估设计用于隔离传染病患者的空气传播感染隔离（AII）病房的性能研究表明，规定的要求和实际测量之间存在重大差异。
我们进行了一项实验研究，以调查使用高通量室内空气净化装置对宿主传染病患者的区域进行补充性的空气污染物防护。该研究包括对空气净化装置针对特定流行病学意义的生物气溶胶的固有性能测试，以及在不同通风情况下的医院 AII 病房的现场测试。
该装置可有效消除空气中的 H5N2 流感病毒和牛分枝杆菌（单轮通过减少 4-5 对数），并且当与室内抽气机一起使用时，可将峰值污染水平降低 5 倍，净化效率比单独使用抽气机至少提高 33%。
高通量的室内空气处理装置可为隔离病房中空气传播病原体水平提供补充控制。
