Department of Immunology and Medical Zoology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
Curr Opin Immunol. 2010 Dec;22(6):814-20. doi: 10.1016/j.coi.2010.10.018. Epub 2010 Nov 20.
Basophils are important effector cells, which contribute to protection against helminths and execute proinflammatory effector function during allergic inflammation. Basophils are also regulators of Th2 responses in helminth-infected hosts and in allergen-injected animals. Recently, three groups using different experimental systems have shown that basophils are antigen-presenting cells (APC), which induce Th2 cells both in vitro and in vivo. Basophils express MHC class II and CD80/86, have the potential to take-up and process protein antigen (Ag), particularly Ag-IgE complexes, and to present peptide with MHC class II and produce IL-4. However, relevance of basophils as Th2 cell-inducing APC in vivo has been challenged by several recent reports that favor the concept that basophils and DC cooperate or basophils merely amplify DC-driven Th2 cell differentiation. In this review, I summarize and discuss the data on the role of basophils as Th2 cell-inducing APC in allergy and parasite infection.
嗜碱性粒细胞是重要的效应细胞，有助于抵抗寄生虫，并在过敏炎症期间执行促炎效应功能。嗜碱性粒细胞也是寄生虫感染宿主和过敏原注射动物中 Th2 反应的调节剂。最近，三个使用不同实验系统的小组表明，嗜碱性粒细胞是抗原呈递细胞 (APC)，可在体外和体内诱导 Th2 细胞。嗜碱性粒细胞表达 MHC Ⅱ类和 CD80/86，具有摄取和处理蛋白质抗原 (Ag)，特别是 Ag-IgE 复合物，并呈递与 MHC Ⅱ类结合的肽和产生 IL-4 的潜力。然而，嗜碱性粒细胞作为体内 Th2 细胞诱导 APC 的相关性受到了几项最近的报告的挑战，这些报告倾向于认为嗜碱性粒细胞和 DC 合作，或者嗜碱性粒细胞仅仅放大了 DC 驱动的 Th2 细胞分化。在这篇综述中，我总结并讨论了关于嗜碱性粒细胞作为诱导 Th2 细胞的 APC 在过敏和寄生虫感染中的作用的数据。
