INSERM, U872, Paris, France.
Trends Immunol. 2010 Feb;31(2):45-8. doi: 10.1016/j.it.2009.12.004. Epub 2010 Jan 8.
Recent reports demonstrate that basophils act as antigen presenting cells to drive Th2 and IgE responses against protease and protein allergens and helminth parasites. Through MHC class II-dependent cognate interactions with CD4(+) T cells in the context of co-stimulatory molecules, and through secretion of IL-4, IL-13 and thymic stromal lymphopoietin, basophils drive antigen-specific Th2 responses. These results have uncovered previously unknown functions of basophils, and should aid in designing novel therapeutic strategies for asthma and allergic conditions.
最近的报告表明，嗜碱性粒细胞作为抗原呈递细胞，可驱动针对蛋白酶和蛋白过敏原及寄生虫的 Th2 和 IgE 应答。通过 MHC Ⅱ类依赖性的、与共刺激分子相关的与 CD4+T 细胞的同源相互作用，以及通过分泌 IL-4、IL-13 和胸腺基质淋巴细胞生成素，嗜碱性粒细胞可驱动抗原特异性 Th2 应答。这些结果揭示了嗜碱性粒细胞以前未知的功能，应该有助于设计哮喘和过敏疾病的新型治疗策略。
