社区获得性细菌性肺炎中的肥胖悖论。

The obesity paradox in community-acquired bacterial pneumonia.

机构信息

Department of Medicine, Division of Infectious Diseases, University of Ottawa, The Ottawa Hospital, 1053 Carling Ave, CPC 470, Ottawa, Ontario, K1Y 4E9, Canada.

出版信息

Int J Infect Dis. 2011 Jan;15(1):e54-7. doi: 10.1016/j.ijid.2010.09.011. Epub 2010 Nov 20.

DOI:10.1016/j.ijid.2010.09.011

PMID:21095152

Abstract

BACKGROUND

The impact of obesity on the outcome of pneumonia is uncertain.

METHODS

We retrospectively identified 266 hospitalized patients with proven pneumococcal or Haemophilus community-acquired pneumonia who had at least one body mass index (BMI, kg/m²) value documented in the 3 months before admission. Patients were classified as underweight (BMI <18.5), normal weight (BMI 18.5 to <25), overweight (BMI 25 to <30), or obese (BMI ≥30). The association of absolute BMI values and BMI categories with the mortality at 30 days after admission for pneumonia was investigated.

RESULTS

Increasing BMI values were associated with reduced 30-day mortality, even after adjustment for significant covariates (odds ratio 0.88, confidence interval 0.81-0.96; p<0.01). There was a significant trend towards lower mortality in the overweight and obese (non-parametric trend, p=0.02).

CONCLUSIONS

Our data suggest that obesity may exert a protective effect against 30-day mortality from community-acquired bacterial pneumonia.

摘要

背景

肥胖对肺炎结局的影响尚不确定。

方法

我们回顾性地确定了 266 例住院的肺炎患者，这些患者均经证实为肺炎链球菌或流感嗜血杆菌社区获得性肺炎，且在入院前 3 个月内至少有一次体重指数（BMI，kg/m²）记录。患者被分为体重不足（BMI＜18.5）、正常体重（BMI 18.5 至＜25）、超重（BMI 25 至＜30）或肥胖（BMI≥30）。研究了绝对 BMI 值和 BMI 类别与肺炎入院后 30 天死亡率之间的关系。