Orofacial Pain and Oral Medicine Center, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90089-0641, USA.
J Prosthodont Res. 2011 Jan;55(1):1-6. doi: 10.1016/j.jpor.2010.09.002. Epub 2010 Nov 20.
The baseline standards for minimally acceptable science are improving as the understanding of the scientific method improves. Journals publishing research papers are becoming more and more rigorous. For example, in 2001 a group of authors evaluated the quality of clinical trials in anesthesia published over a 20 year period [Pua et al., Anesthesiology 2001;95:1068-73]. The authors divided the time into 3 subgroups and analyzed and compared the quality assessment score from research papers in each group. The authors reported that the scientific quality scores increased significantly in this time, showing more randomization, sample size calculation and blinding of studies. Because every journal strives to have a high scientific impact factor, research quality is critical to this goal. This means novice researchers must study, understand and rigorously avoid the common mistakes described in this review. Failure to do so means the hundreds and hundreds of hours of effort it takes to conduct and write up a clinical trial will be for naught, in that the manuscript with be rejected or worse yet, ignored. All scientists have a responsibility to understand research methods, conduct the best research they can and publish the honest and unbiased results.
随着对科学方法理解的不断提高，最低可接受科学标准正在提高。发表研究论文的期刊越来越严格。例如，2001 年，一组作者评估了在 20 年期间发表的麻醉临床研究的质量[Pua 等人，麻醉学 2001 年；95：1068-73]。作者将时间分为 3 个亚组，并分析和比较了每组研究论文的质量评估分数。作者报告说，在此期间，科学质量分数显著提高，表明研究中的随机化、样本量计算和盲法更多。由于每个期刊都努力提高科学影响力因素，因此研究质量对于实现这一目标至关重要。这意味着新手研究人员必须学习、理解并严格避免本综述中描述的常见错误。如果不这样做，那么花费数百小时进行和撰写临床试验的努力将是徒劳的，因为手稿将被拒绝，更糟糕的是，被忽视。所有科学家都有责任了解研究方法，进行他们能够进行的最佳研究，并发表诚实和无偏见的结果。
