Dept. of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Int J Pharm. 2011 Apr 15;408(1-2):1-8. doi: 10.1016/j.ijpharm.2010.11.031. Epub 2010 Nov 21.
The object of this study was to investigate the influence of static and dynamic forces on mechanical properties of the biocompatible polymer ethyl cellulose. Similar polymeric films containing 40% (w/w) of the plasticizer dibutyl sebacate were subjected to tensile forces at different velocities. The average Young's modulus and the variation of yield strength, strain, and strain energy at different velocities complied with the pre-established theories of dynamic loadings. The ultimate strength and the yield strength and/or strain displayed linearity with the velocity, though the ultimate strain and therefore, the plastic and/or ultimate working energies proved non-linear pseudo-Michaelis-Menten behavior. The speculation was that achieving the maximum displacement would probably be the most important cause of failure. Finally the most suitable velocity at which the data would obtain the most demonstrable stress-strain diagrams was selected: tensile forces at almost low velocities, best illustrated as static forces, proved immature failure of the specimens during or shortly after the yield; so that the specimen resembled as a brittle material. High velocities of loadings were also avoided since the strain would usually approach the plateau and would therefore disrupt the rational correlation between forces and displacements during the end region of the curve.
本研究旨在探讨静态和动态力对生物相容性聚合物乙基纤维素力学性能的影响。相似的含有 40%(重量/重量)增塑剂癸二酸二丁酯的聚合薄膜在不同速度下受到拉伸力。平均杨氏模量和屈服强度、应变和应变能的变化与预先设定的动态载荷理论一致。极限强度和屈服强度和/或应变与速度呈线性关系,而极限应变以及因此的塑性和/或极限工作能量则表现出非线性拟米氏-门登行为。推测达到最大位移可能是失效的最重要原因。最后,选择了最适合获得最明显的应力-应变图的数据的速度:在几乎低速度下施加拉伸力,最好表现为静态力,证明了在屈服期间或之后不久,试样的失效不成熟;因此,试样表现为脆性材料。也避免了高速度的加载,因为应变通常会接近平台,因此会在曲线的末端区域破坏力和位移之间的合理相关性。