Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
Int Rev Neurobiol. 2010;95:29-47. doi: 10.1016/B978-0-12-381326-8.00003-X.
Old and new results show that both catechol-O-methyltransferase (COMT) forms are found in all mouse tissues, demonstrating that COMT is a ubiquitous enzyme. Some novel findings are obvious when considering differences between old and new distribution data. In addition to the brain, membrane-bound form of COMT (MB-COMT) is found also in most peripheral mouse tissues at about equal amounts as soluble form of COMT (S-COMT), suggesting that their functions do not need to be very different. There are large differences between the species in the relative distribution of S-COMT and MB-COMT. According to the new data, it is evident that even in the animal tissues MB-COMT is not associated with the plasma membranes but with intracellular membranes, and that S-COMT resides not only in the cytoplasm but even in the nucleus.
新旧研究结果均表明，两种儿茶酚-O-甲基转移酶（COMT）同工酶均存在于所有的鼠组织中，证明 COMT 是一种普遍存在的酶。当考虑新旧分布数据的差异时，一些新的发现是显而易见的。除了大脑之外，在大多数外周鼠组织中也发现了膜结合形式的 COMT（MB-COMT），其含量与可溶性 COMT（S-COMT）大致相同，这表明它们的功能不需要有很大的差异。在 S-COMT 和 MB-COMT 的相对分布方面，不同物种之间存在很大差异。根据新数据，显然即使在动物组织中，MB-COMT 也不与质膜相关联，而是与细胞内膜相关联，并且 S-COMT 不仅存在于细胞质中，甚至存在于细胞核中。
