Wilson Emma, Rustighi Emiliano, Newland Philip L, Mace Brian R
Institute of Sound and Vibration Research, University of Southampton, SO17 1BJ, United Kingdom.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:4517-20. doi: 10.1109/IEMBS.2010.5626056.
A predictive model that can be used to estimate the isometric force response of the locust hind leg extensor muscle is presented. The model consists of two first order coupled differential equations. The first of these equations is linear and relates an input pulse train to the calcium concentration in muscle filaments. The second is non-linear and relates the calcium concentration to muscle force. Experimental data was collected by stimulating the extensor muscle and measuring the force generated at the tibia. Model parameters were estimated by minimising the error between the modelled and actual force response in a set of training data. These parameters were then used to predict the isometric response when the neural activity recorded during a kick was used as an input to the model. The model was found to accurately predict the isometric force response of the locust hind leg extensor muscle.
本文提出了一种可用于估计蝗虫后腿伸肌等长力响应的预测模型。该模型由两个一阶耦合微分方程组成。其中第一个方程是线性的，将输入脉冲序列与肌丝中的钙浓度联系起来。第二个方程是非线性的，将钙浓度与肌肉力量联系起来。通过刺激伸肌并测量胫骨产生的力量来收集实验数据。通过最小化一组训练数据中建模力响应与实际力响应之间的误差来估计模型参数。然后，当将踢腿过程中记录的神经活动用作模型输入时，使用这些参数来预测等长响应。结果发现该模型能够准确预测蝗虫后腿伸肌的等长力响应。
