Green R A, Devillaine F, Dodds C, Matteucci P, Chen S, Byrnes-Preston P, Poole-Warren L A, Lovell N H, Suaning G J
Graduate School of Biomedical Engineering, University of New South Wales, Australia.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:6769-72. doi: 10.1109/IEMBS.2010.5625993.
Conducting polymers (CPs) have the potential to provide superior neural interfaces to conventional metal electrodes by introducing more efficient charge transfer across the same geometric area. In this study the conducting polymer poly(ethylene dioxythiophene) (PEDOT) was coated on platinum (Pt) microelectrode arrays. The in vitro electrical characteristics were assessed during biphasic stimulation regimes applied between electrode pairs. It was demonstrated that PEDOT could reduce the potential excursion at a Pt electrode interface by an order of magnitude. The charge injection limit of PEDOT was found to be 15 x larger than Pt. Additionally, PEDOT coated electrodes were acutely implanted in the suprachoroidal space of a cat retina. It was demonstrated that PEDOT coated electrodes also had lower potential excursions in vivo and electrically evoked potentials (EEPs) could be detected within the vision cortex.
导电聚合物（CPs）有潜力通过在相同几何面积上实现更高效的电荷转移，为传统金属电极提供更优异的神经接口。在本研究中，导电聚合物聚（3,4 - 乙撑二氧噻吩）（PEDOT）被涂覆在铂（Pt）微电极阵列上。在电极对之间施加双相刺激方案期间评估了其体外电学特性。结果表明，PEDOT可使Pt电极界面处的电位偏移降低一个数量级。发现PEDOT的电荷注入极限比Pt大15倍。此外，将涂有PEDOT的电极急性植入猫视网膜的脉络膜上腔。结果表明，涂有PEDOT的电极在体内也具有较低的电位偏移，并且在视觉皮层内可检测到电诱发反应（EEPs）。
