Verma A K
Department of Human Oncology, University of Wisconsin Clinical Cancer Center, Madison 53792.
Basic Life Sci. 1990;52:195-204. doi: 10.1007/978-1-4615-9561-8_16.
Knowledge of the mechanisms of carcinogenesis is helpful for planning strategies and in the rational choice of agents for cancer prevention. There is a great potential for intervention at the promotion step of human carcinogenesis. ODC induction is associated with the promotion stage of carcinogenesis. Consequently, DFMO may be a useful drug for cancer prevention in humans. Long-term medication with higher doses (9 gm/m2/da) of DFMO has resulted in several toxic side effects, such as thrombocytopenia and reversible ototoxicity. However, doses of DFMO (less than 1 gm/m2/da), selected by our in vitro human skin punch biopsy assay (16, 47), may be given for a longer period without appreciable toxicity and should be evaluated in human cancer prevention trials.
了解致癌机制有助于规划癌症预防策略以及合理选择预防药物。在人类致癌作用的促进阶段进行干预具有很大潜力。鸟氨酸脱羧酶（ODC）的诱导与致癌作用的促进阶段相关。因此，二氟甲基鸟氨酸（DFMO）可能是一种对人类癌症预防有用的药物。长期服用高剂量（9克/平方米/天）的DFMO会导致多种毒副作用，如血小板减少和可逆性耳毒性。然而，根据我们的体外人体皮肤打孔活检试验（16, 47）选择的DFMO剂量（小于1克/平方米/天），可以较长时间给药而无明显毒性，应在人类癌症预防试验中进行评估。
