面向基于开关电容的高效深部脑刺激刺激器。
Towards a Switched-Capacitor based Stimulator for efficient deep-brain stimulation.
作者信息
Vidal Jose, Ghovanloo Maysam
机构信息
Electrical and Computer Engineering Department, Georgia Institute of Technology, Atlanta, GA 30308, USA.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:2927-30. doi: 10.1109/IEMBS.2010.5626290.
We have developed a novel 4-channel prototype stimulation circuit for implantable neurological stimulators (INS). This Switched-Capacitor based Stimulator (SCS) aims to utilize charge storage and charge injection techniques to take advantage of both the efficiency of conventional voltage-controlled stimulators (VCS) and the safety and controllability of current-controlled stimulators (CCS). The discrete SCS prototype offers fine control over stimulation parameters such as voltage, current, pulse width, frequency, and active electrode channel via a LabVIEW graphical user interface (GUI) when connected to a PC through USB. Furthermore, the prototype utilizes a floating current sensor to provide charge-balanced biphasic stimulation and ensure safety. The stimulator was analyzed using an electrode-electrolyte interface (EEI) model as well as with a pair of pacing electrodes in saline. The primary motivation of this research is to test the feasibility and functionality of a safe, effective, and power-efficient switched-capacitor based stimulator for use in Deep Brain Stimulation.
我们为植入式神经刺激器（INS）开发了一种新型的4通道原型刺激电路。这种基于开关电容的刺激器（SCS）旨在利用电荷存储和电荷注入技术，兼具传统电压控制刺激器（VCS）的效率以及电流控制刺激器（CCS）的安全性和可控性。当通过USB连接到个人计算机时，离散式SCS原型可通过LabVIEW图形用户界面（GUI）对刺激参数（如电压、电流、脉冲宽度、频率和有源电极通道）进行精细控制。此外，该原型利用一个浮动电流传感器来提供电荷平衡的双相刺激并确保安全性。使用电极 - 电解质界面（EEI）模型以及在盐水中的一对起搏电极对该刺激器进行了分析。本研究的主要目的是测试一种用于深部脑刺激的安全、有效且节能的基于开关电容的刺激器的可行性和功能。
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