Nogueira S, Ferreira E, Geisinger D, San Román C, Suarez H
Laboratory of Otoneurology, British Hospital, CLAEH School of Medicine, Av. Italia, 2364/704, Montevideo, Uruguay.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:5452-5. doi: 10.1109/IEMBS.2010.5626509.
In this study a simple model of the postural control system is implemented and its parameters are adjusted to explain the differences between Parkinson's disease patient's measures and healthy young adult's measures by performing simulations of spontaneous sway with center-of-pressure traces. An optimization procedure was performed varying four parameters of the model. The best adjustment obtained was when the proportional and derivative factors where the same as for healthy young adults and noise level gain and force feedback gain varied independently. Differences in the latter parameter can be explained because of insufficient and slowed force production necessary to counteract perturbations in Parkinson's disease patients while the former may be due to noise in the sensory system that estimates the vertical deviation angle and/or perturbations in the execution of the movement.
在本研究中，实现了一个简单的姿势控制系统模型，并通过对压力中心轨迹的自发摆动进行模拟，调整其参数以解释帕金森病患者测量值与健康年轻成年人测量值之间的差异。执行了一个优化程序，改变模型的四个参数。得到的最佳调整是比例因子和微分因子与健康年轻成年人相同，噪声水平增益和力反馈增益独立变化。后一个参数的差异可以解释为帕金森病患者抵消扰动所需的力产生不足且缓慢，而前一个参数的差异可能是由于估计垂直偏差角度的感觉系统中的噪声和/或运动执行中的扰动。
