Waterston J A, Hawken M B, Tanyeri S, Jäntti P, Kennard C
Department of Neurology, Royal London Hospital, UK.
J Neurol Neurosurg Psychiatry. 1993 Dec;56(12):1276-81. doi: 10.1136/jnnp.56.12.1276.
Postural control was assessed on a tilting platform system in 20 patients with idiopathic Parkinson's disease and 20 age-matched controls. The amount of information provided by vision and lower limb proprioception was varied during the experiment to investigate the influence of changes in sensory cues on postural control. The patient group with clinical evidence of impaired postural control (Hoehn and Yahr III) had significantly higher sway scores over all sensory conditions than either the Hoehn and Yahr II group or controls. The pattern of sway scores indicated that no obvious deficit in the quality, or processing, of sensory information was responsible for the postural instability observed in this group. The patients in both Hoehn and Yahr groups were also able to respond appropriately to potentially destabilising sensory conflict situations and significantly improved their sway scores when provided with visual feedback of body sway. The results indicate that in Parkinson's disease, the main site of dysfunction in postural control is likely to be at a central motor level.
在一个倾斜平台系统上对20例特发性帕金森病患者和20例年龄匹配的对照者进行姿势控制评估。在实验过程中，视觉和下肢本体感觉所提供的信息量有所变化，以研究感觉线索变化对姿势控制的影响。有姿势控制受损临床证据（Hoehn和Yahr III级）的患者组在所有感觉条件下的摇摆分数均显著高于Hoehn和Yahr II级组或对照组。摇摆分数模式表明，该组中观察到的姿势不稳定并非由感觉信息的质量或处理方面的明显缺陷所致。Hoehn和Yahr两组的患者也能够对潜在的使姿势不稳定的感觉冲突情况做出适当反应，并且在获得身体摇摆的视觉反馈时，其摇摆分数显著改善。结果表明，在帕金森病中，姿势控制功能障碍的主要部位可能在中枢运动水平。
