心脏动作电位的通用离子模型。
A generic ionic model of cardiac action potentials.
作者信息
Guo Tianruo, Abed Amr Al, Lovell Nigel H, Dokos Socrates
机构信息
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, 2052, Australia.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:1465-8. doi: 10.1109/IEMBS.2010.5626853.
A generic cardiac ionic model employing membrane currents based on two-gate Hodgkin-Huxley kinetics is presented. Its generic nature allows it to accurately reproduce action potential waveforms in heterogeneous cardiac tissue by optimizing parameters governing ion channel kinetics and magnitudes. The model allows a user-defined number of voltage and time-dependent ion currents to be incorporated, in order to reproduce and predict electrophysiological action potential waveforms from multiple recordings in individual cardiac myocytes.
提出了一种基于双门控霍奇金-赫胥黎动力学的膜电流通用心脏离子模型。其通用性使其能够通过优化控制离子通道动力学和大小的参数，准确再现异质性心脏组织中的动作电位波形。该模型允许纳入用户定义数量的电压和时间依赖性离子电流，以便从单个心肌细胞的多个记录中再现和预测电生理动作电位波形。
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