格列本脲与美托拉宗之间可能存在蛋白质结合置换相互作用。
Possible protein binding displacement interaction between glibenclamide and metolazone.
作者信息
George S, McBurney A, Cole A
机构信息
Department of Clinical Pharmacology, Glenfield General Hospital, Leicester, UK.
出版信息
Eur J Clin Pharmacol. 1990;38(1):93-5. doi: 10.1007/BF00314813.
PMID:2109700
Abstract
The effects of metolazone on the protein binding of glibenclamide were studied. It was found that increasing metolazone concentrations up to 100 ng/ml had no significant effect on the protein binding of glibenclamide studied at 10 micrograms/ml. Metolazone is unlikely to cause a clinically significant increase in the free fraction of glibenclamide in patients receiving both drugs.
摘要
研究了美托拉宗对格列本脲蛋白结合率的影响。结果发现，将美托拉宗浓度增至100 ng/ml，对10μg/ml格列本脲的蛋白结合率并无显著影响。对于同时服用这两种药物的患者，美托拉宗不太可能导致格列本脲的游离部分出现具有临床意义的增加。
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