对大脑中光诱导神经活动进行成像。
Imaging optically induced neural activity in the brain.
作者信息
Mahadevan-Jansen Anita, Cayce Jonathan M, Friedman Robert, Roe Anna W, Konrad Peter E, Hillman Elizabeth, Jansen E
机构信息
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235 USA.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:3379-81. doi: 10.1109/IEMBS.2010.5627920.
Infrared neural stimulation (INS) is well characterized for the peripheral nervous system; however, translation to the central nervous system (CNS) presents a new set of challenges which require us to consider different anatomy, multiple cell types, and the physiology associated with structures in the CNS. This study presents our first attempt to translate INS to in vivo stimulation of the CNS and to image the related response. The results from this study show that INS generates intrinsic optical signals of similar magnitude and shape associated with well characterized mechanical stimuli. The implications of this work could lead to neural implants which allows for single cell stimulation making it possible to design closed loop neural prosthetics.
红外神经刺激（INS）在外周神经系统中已有充分的特征描述；然而，将其应用于中枢神经系统（CNS）则带来了一系列新的挑战，这要求我们考虑不同的解剖结构、多种细胞类型以及与中枢神经系统结构相关的生理学特性。本研究首次尝试将INS应用于中枢神经系统的体内刺激并对相关反应进行成像。这项研究的结果表明，INS会产生与特征明确的机械刺激相关的、幅度和形状相似的内在光信号。这项工作的意义可能会带来神经植入物，实现单细胞刺激，从而有可能设计出闭环神经假体。
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