Lamanna Jacopo, Esposti Federico, Signorini Maria G
Dipartimento di Bioingegneria, Politecnico di Milano, piazza Leonardo da Vinci, 32, 20133, Italy.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:4842-5. doi: 10.1109/IEMBS.2010.5628017.
This methodological work is aimed at providing a Granger causality based approach to the study of neuronal networks development in vitro. The analysis procedure makes use of tools derived from statistics and network theory for accessing network development of in-vitro neuronal cultures from their electrical activity, recorded through Multi Electrode Arrays (MEAs). The preliminary results that will be presented here show the potential of this approach for characterizing in a quantitative way the developmental stages of neuronal networks and provide some evidences which are consistent with direct in-vitro and in-vivo observations reported by other authors.
这项方法学研究旨在提供一种基于格兰杰因果关系的方法，用于体外神经元网络发育的研究。分析过程利用了源自统计学和网络理论的工具，通过多电极阵列（MEA）记录体外神经元培养物的电活动，从而了解其网络发育情况。本文将展示的初步结果表明，这种方法具有以定量方式表征神经元网络发育阶段的潜力，并提供了一些与其他作者报告的直接体外和体内观察结果一致的证据。
