Massobrio Paolo, Pasquale Valentina, Martinoia Sergio
Annu Int Conf IEEE Eng Med Biol Soc. 2015;2015:4737-40. doi: 10.1109/EMBC.2015.7319452.
In vitro neuronal networks coupled to Micro-Electrode Arrays (MEAs) represent a valid experimental framework to study neuronal dynamics. This preparation is free of chemical or physical constraints and allows neurons to self-organize during development, creating networks that exhibit complex spatio-temporal patterns of activity. Starting from this experimental evidence, here we address the question whether a particular network architecture can drive the network dynamics towards a sub-, super-, or critical state.
与微电极阵列（MEA）耦合的体外神经元网络是研究神经元动力学的有效实验框架。这种制备方法不受化学或物理限制，允许神经元在发育过程中自我组织，形成表现出复杂时空活动模式的网络。基于这一实验证据，我们在此探讨一个问题，即特定的网络架构是否能将网络动力学驱动至亚临界、超临界或临界状态。
