父母和老师对接受癌症治疗的儿童进行为期一年的哌醋甲酯治疗期间注意力的评定。
Parent and teacher ratings of attention during a year-long methylphenidate trial in children treated for cancer.
机构信息
Department of Psychology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 740, Memphis, TN 38105, USA.
出版信息
J Pediatr Psychol. 2011 May;36(4):438-50. doi: 10.1093/jpepsy/jsq102. Epub 2010 Nov 19.
Abstract
OBJECTIVE
Longitudinally examine attention performance in childhood cancer survivors prescribed methylphenidate (MPH) to ameliorate cognitive late effects, comparing measures for inter-rater and inter-method discrepancies.
METHODS
Survivors of acute lymphoblastic leukemia (n = 33) or brain tumor (n = 35), mean age 11.11 ± 0.37 years, completed a 12-month, open-label trial of MPH. Conners' Parent and Teacher Rating Scales were completed at baseline, 1, 3, 6, and 12 months. The Conners' Continuous Performance Test (CPT) was completed at baseline and 12 months.
RESULTS
Improved attention was reported after 1 month of MPH (p < .05), with relative stability throughout the trial. Inter-rater agreement was low-to-moderate (ICC = -.06 to .46). Observer ratings correlated with select CPT indices at baseline (p < .05), but not at 12 months.
CONCLUSIONS
Childhood cancer survivors' attention improved after 1 month on MPH. Modest agreement between parents and teachers, and low-to-moderate correlations between behavior ratings and performance-based attention measures highlight a need for multimodal assessment.
摘要
目的
纵向研究服用哌醋甲酯（MPH）改善认知晚期效应的儿童癌症幸存者的注意力表现，比较组内和组间差异的测量方法。
方法
急性淋巴细胞白血病（n=33）或脑肿瘤（n=35）幸存者，平均年龄 11.11±0.37 岁，完成了为期 12 个月的 MPH 开放性试验。在基线、1、3、6 和 12 个月时完成康纳斯父母和教师评定量表。在基线和 12 个月时完成康纳斯连续执行测试（CPT）。
结果
在 MPH 治疗 1 个月后，注意力得到改善（p<0.05），整个试验过程中相对稳定。组内观察者间的一致性为低到中度（ICC=-.06 至.46）。在基线时，观察评分与部分 CPT 指标相关（p<0.05），但在 12 个月时不相关。
结论
儿童癌症幸存者在服用 MPH 1 个月后注意力提高。父母和教师之间的一致性适中，行为评分与基于表现的注意力测量之间的相关性低到中度，这突出表明需要进行多模态评估。
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