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分支杆菌属的肽聚糖主要通过 L,D-转肽酶交联。

The peptidoglycan of Mycobacterium abscessus is predominantly cross-linked by L,D-transpeptidases.

机构信息

LRMA, Equipe 12, Centre de Recherches des Cordeliers, 15 rue de l'Ecole de Médecine, 75270 Paris Cedex 06, France.

出版信息

J Bacteriol. 2011 Feb;193(3):778-82. doi: 10.1128/JB.00606-10. Epub 2010 Nov 19.

DOI:10.1128/JB.00606-10
PMID:21097619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3021224/
Abstract

Few therapeutic alternatives remain for the treatment of infections due to multiresistant Mycobacterium abscessus. Here we show that the peptidoglycans of the "rough" and "smooth" morphotypes contain predominantly 3→3 cross-links generated by l,d-transpeptidases, indicating that these enzymes are attractive targets for the development of efficient drugs.

摘要

由于耐多药脓肿分枝杆菌感染的治疗选择有限。在这里，我们表明“粗糙”和“光滑”形态型的肽聚糖主要含有 l,d-转肽酶产生的 3→3 交联，表明这些酶是开发有效药物的有吸引力的靶标。

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Nat Med. 2010 Apr;16(4):466-9. doi: 10.1038/nm.2120. Epub 2010 Mar 21.
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The beta-lactam-sensitive D,D-carboxypeptidase activity of Pbp4 controls the L,D and D,D transpeptidation pathways in Corynebacterium jeikeium.β-内酰胺敏感的 D,D-羧肽酶活性的 Pbp4 可控制棒状杆菌属 D,L 和 D,D 转肽途径。
Mol Microbiol. 2009 Nov;74(3):650-61. doi: 10.1111/j.1365-2958.2009.06887.x. Epub 2009 Oct 6.
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