分支杆菌属的肽聚糖主要通过 L,D-转肽酶交联。
The peptidoglycan of Mycobacterium abscessus is predominantly cross-linked by L,D-transpeptidases.
机构信息
LRMA, Equipe 12, Centre de Recherches des Cordeliers, 15 rue de l'Ecole de Médecine, 75270 Paris Cedex 06, France.
出版信息
J Bacteriol. 2011 Feb;193(3):778-82. doi: 10.1128/JB.00606-10. Epub 2010 Nov 19.
Abstract
Few therapeutic alternatives remain for the treatment of infections due to multiresistant Mycobacterium abscessus. Here we show that the peptidoglycans of the "rough" and "smooth" morphotypes contain predominantly 3→3 cross-links generated by l,d-transpeptidases, indicating that these enzymes are attractive targets for the development of efficient drugs.
摘要
由于耐多药脓肿分枝杆菌感染的治疗选择有限。在这里，我们表明“粗糙”和“光滑”形态型的肽聚糖主要含有 l,d-转肽酶产生的 3→3 交联，表明这些酶是开发有效药物的有吸引力的靶标。
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