Division of Cardiology, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
J Cardiovasc Pharmacol Ther. 2010 Dec;15(4 Suppl):6S-14S. doi: 10.1177/1074248410377618.
Although originally synthesized as an antianginal compound, amiodarone has emerged as an effective antiarrhythmic for both supraventricular and ventricular arrhythmias. Over the decades, the properties, the effectiveness, the merits as well as the shortcomings of the compound have been well established. The major limitations of this agent are mainly due to the systemic side effects seen with prolonged therapy. Many of the toxic effects observed are primarily caused by the high iodine content present in the amiodarone molecule. Dronedarone, the first noniodinated amiodarone congener, has been developed largely to obtain the antiarrhythmic efficacy in the control of atrial fibrillation without the known adverse side effects of dronedarone. In this part of the supplement, the focus is the electrophysiological effects of dronedarone with the characterization in normal cardiac cells, in animal models of disease, as well as in human studies.
虽然胺碘酮最初是作为一种抗心绞痛化合物合成的，但它已成为一种治疗室上性和室性心律失常的有效抗心律失常药物。几十年来，该化合物的性质、有效性、优点和缺点已经得到了充分的证实。该药物的主要局限性主要是由于长期治疗中出现的全身副作用。许多观察到的毒性作用主要是由胺碘酮分子中存在的高碘含量引起的。多非利特是第一个非碘代胺碘酮同系物，主要是为了在不引起多非利特已知不良反应的情况下获得控制心房颤动的抗心律失常疗效而开发的。在这部分补充中，重点是多非利特的电生理作用，包括在正常心脏细胞、疾病动物模型以及人类研究中的特征。
