Saengklub Nakkawee, Youngblood Brad, Del Rio Carlos, Sawangkoon Suwanakiet, Hamlin Robert L, Kijtawornrat Anusak
Graduate Student in the Program of Animal Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand.
J Vet Med Sci. 2016 Jul 1;78(6):977-85. doi: 10.1292/jvms.15-0481. Epub 2016 Feb 26.
Dronedarone is a multichannel blocking antiarrhythmic drug that has been used for management of atrial fibrillation in humans, but the data in veterinary medicine are inadequate. The objective of this study was to determine the short-term effects of oral dronedarone on cardiac inotropy and lusitropy, blood pressure and electrocardiogram (ECG) in healthy dogs. A total of 6 beagle dogs were instrumented with telemetry units and sono-micrometry crystals to obtain left ventricular pressure-volume relationship, mean blood pressure (MBP) and ECG. Dogs were given orally dronedarone (20 mg/kg, twice per day) for 7 days. All parameters were obtained hourly at 4-8 hr after the first dose and at 12-, 96- (day 4) and 168-hr (day 7) after dosing. The results showed that dronedarone had no effect on inotropy and lusitropy, while it significantly lengthened PQ interval (P<0.001) and lowered MBP (P<0.05). Dronedarone also tended to reduce cardiac output (P=0.237) and heart rate (P=0.057). These results suggested that short-term effects of oral dronedarone administration at a dose of 20 mg/kg, twice per day, produced negative dromotropy with minimal effect on cardiac function in conscious dogs.
决奈达隆是一种多通道阻断抗心律失常药物，已用于人类心房颤动的治疗，但兽医学方面的数据尚不充分。本研究的目的是确定口服决奈达隆对健康犬心脏收缩性和舒张性、血压及心电图（ECG）的短期影响。总共6只比格犬被植入遥测装置和超声测微晶体，以获取左心室压力-容积关系、平均血压（MBP）和ECG。给犬口服决奈达隆（20mg/kg，每日两次），持续7天。在首次给药后4-8小时以及给药后12、96小时（第4天）和168小时（第7天）每小时获取所有参数。结果显示，决奈达隆对收缩性和舒张性无影响，但显著延长PQ间期（P<0.001）并降低MBP（P<0.05）。决奈达隆还倾向于降低心输出量（P=0.237）和心率（P=0.057）。这些结果表明，每天两次口服20mg/kg决奈达隆的短期效应在清醒犬中产生负性变传导作用，对心脏功能影响最小。
