Mattle H, Edelman R R, Reis M A, Atkinson D J
Harvard Medical School, New England Deaconess Hospital, Boston, MA.
Neurology. 1990 May;40(5):813-5. doi: 10.1212/wnl.40.5.813.
To date, the intracerebral veins and venous sinuses have not been amenable to noninvasive study. We describe a magnetic resonance (MR) technique using "bolus tracking" for rapid imaging and measurement of cerebral venous flow. We specifically applied the technique to the superior sagittal sinus, but it can be used for evaluation of other cerebral venous structures. In 10 healthy subjects and 21 patients referred for MR brain studies, mean flow was 420 ml/min. There was a significant inverse correlation between blood flow and age. There were dynamic changes in cerebral blood flow (CBF) during hyperventilation and hypercapnia. Since the cerebral cortex drains almost exclusively to the superior sagittal sinus, these flow measurements represent an index of global CBF. MR flow quantification provides a new means for assessing dynamic changes in CBF, and may prove useful for monitoring the effects of various disease processes and pharmaceutical agents on CBF.
迄今为止，脑内静脉和静脉窦一直无法进行无创性研究。我们描述了一种利用“团注追踪”的磁共振（MR）技术，用于快速成像和测量脑静脉血流。我们特别将该技术应用于上矢状窦，但它也可用于评估其他脑静脉结构。在10名健康受试者和21名因脑部MR检查而转诊的患者中，平均血流为420毫升/分钟。血流与年龄之间存在显著的负相关。在过度换气和高碳酸血症期间，脑血流量（CBF）会发生动态变化。由于大脑皮质几乎完全引流至上矢状窦，这些血流测量值代表了整体CBF的一个指标。MR血流定量分析为评估CBF的动态变化提供了一种新方法，可能对监测各种疾病过程和药物对CBF的影响有用。
