一个保守的生殖系多能性程序。
A conserved germline multipotency program.
机构信息
Department of Molecular and Cellular Biology, Brown University, Providence, RI 02912, USA.
出版信息
Development. 2010 Dec;137(24):4113-26. doi: 10.1242/dev.047969.
Abstract
The germline of multicellular animals is segregated from somatic tissues, which is an essential developmental process for the next generation. Although certain ecdysozoans and chordates segregate their germline during embryogenesis, animals from other taxa segregate their germline after embryogenesis from multipotent progenitor cells. An overlapping set of genes, including vasa, nanos and piwi, operate in both multipotent precursors and in the germline. As we propose here, this conservation implies the existence of an underlying germline multipotency program in these cell types that has a previously underappreciated and conserved function in maintaining multipotency.
摘要
多细胞动物的生殖细胞与体细胞组织分离，这是下一代的一个重要发育过程。尽管某些节肢动物和脊索动物在胚胎发生过程中分离生殖细胞，但来自其他分类群的动物在胚胎发生后从多能祖细胞中分离生殖细胞。包括 vasa、nanos 和 piwi 在内的一组重叠基因在多能前体细胞和生殖细胞中都起作用。正如我们在这里提出的那样，这种保守性意味着这些细胞类型中存在一个潜在的生殖细胞多能性程序，它在维持多能性方面具有以前被低估和保守的功能。
相似文献
1
A conserved germline multipotency program.
Development. 2010 Dec;137(24):4113-26. doi: 10.1242/dev.047969.
2
Regeneration of the germline in the annelid Capitella teleta.
Dev Biol. 2018 Aug 15;440(2):74-87. doi: 10.1016/j.ydbio.2018.05.004. Epub 2018 May 19.
3
Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid .
Biology (Basel). 2023 Dec 10;12(12):1508. doi: 10.3390/biology12121508.
4
A tumor suppressor Retinoblastoma1 is essential for embryonic development in the sea urchin.
Dev Dyn. 2019 Dec;248(12):1273-1285. doi: 10.1002/dvdy.113. Epub 2019 Oct 1.
5
A comparison study in the proteomic signatures of multipotent germline stem cells, embryonic stem cells, and germline stem cells.
Biochem Biophys Res Commun. 2007 Feb 9;353(2):259-67. doi: 10.1016/j.bbrc.2006.12.025. Epub 2006 Dec 13.
6
Developmental expression of Apnanos during oogenesis and embryogenesis in the parthenogenetic pea aphid Acyrthosiphon pisum.
Int J Dev Biol. 2009;53(1):169-76. doi: 10.1387/ijdb.082570cc.
7
The role of PIWI and the miRNA machinery in Drosophila germline determination.
Curr Biol. 2006 Oct 10;16(19):1884-94. doi: 10.1016/j.cub.2006.08.051. Epub 2006 Aug 31.
8
Germ Line Mechanics--And Unfinished Business.
Curr Top Dev Biol. 2016;117:553-66. doi: 10.1016/bs.ctdb.2015.11.030. Epub 2016 Jan 7.
9
Establishing the germline in spiralian embyos.
Int J Dev Biol. 2014;58(6-8):403-11. doi: 10.1387/ijdb.140125nr.
10
Nanos functions to maintain the fate of the small micromere lineage in the sea urchin embryo.
Dev Biol. 2010 Jan 15;337(2):220-32. doi: 10.1016/j.ydbio.2009.10.030. Epub 2009 Oct 28.
引用本文的文献
1
The Early Evolution of Tudor Genes in Holozoa and How Their Distribution Was Influenced by Life History Traits in Metazoa.
Genome Biol Evol. 2025 May 30;17(6). doi: 10.1093/gbe/evaf051.
2
Vertical Cancer Transmission via Asexual Fragmentation and Associated Cancer Prevalence.
Evol Appl. 2025 May 21;18(5):e70111. doi: 10.1111/eva.70111. eCollection 2025 May.
3
The first embryo, the origin of cancer and animal phylogeny. V. Cancer stem cells as the unifying biomechanical principle between embryology and oncology.
Mechanobiol Med. 2024 Dec 5;3(1):100110. doi: 10.1016/j.mbm.2024.100110. eCollection 2025 Mar.
4
Molecular evidence for pre-chordate origins of ovarian cell types and neuroendocrine control of reproduction.
bioRxiv. 2025 Mar 28:2025.03.24.644836. doi: 10.1101/2025.03.24.644836.
5
Automated, high-throughput in-situ hybridization of embryos.
bioRxiv. 2025 Mar 24:2025.03.23.644641. doi: 10.1101/2025.03.23.644641.
6
Sex-biased gene expression precedes sexual dimorphism in the agonadal annelid Platynereis dumerilii.
Development. 2025 Apr 1;152(7). doi: 10.1242/dev.204513. Epub 2025 Apr 16.
7
The Hydractinia cell atlas reveals cellular and molecular principles of cnidarian coloniality.
Nat Commun. 2025 Mar 3;16(1):2121. doi: 10.1038/s41467-025-57168-z.
8
Regeneration in the absence of canonical neoblasts in an early branching flatworm.
Nat Commun. 2025 Jan 31;16(1):1232. doi: 10.1038/s41467-024-54716-x.
9
Molecular profiles, sources and lineage restrictions of stem cells in an annelid regeneration model.
Nat Commun. 2024 Nov 18;15(1):9882. doi: 10.1038/s41467-024-54041-3.
10
A population of Vasa2 and Piwi1 expressing cells generates germ cells and neurons in a sea anemone.
Nat Commun. 2024 Oct 10;15(1):8765. doi: 10.1038/s41467-024-52806-4.
本文引用的文献
1
Study of the Lineage and Cell Cycle of Small Micromeres in Embryos of the Sea Urchin, Hemicentrotus pulcherrimus: (small micromeres/cell cycle/cell lineage/unequal cleavage/sea urchin).
Dev Growth Differ. 1990 Apr;32(2):145-156. doi: 10.1111/j.1440-169X.1990.00145.x.
2
Germ Cell Differentiation in Starfish: The Posterior Enterocoel as the Origin of Germ Cells in Asterina pectinifera: (starfish/germ cells/PGC/posterior enterocoel/haemal sinus).
Dev Growth Differ. 1992 Aug;34(4):413-418. doi: 10.1111/j.1440-169X.1992.00413.x.
3
Evolution of the bilaterian germ line: lineage origin and modulation of specification mechanisms.
Integr Comp Biol. 2007 Nov;47(5):770-85. doi: 10.1093/icb/icm027. Epub 2007 May 22.
4
Post-translational regulation by gustavus contributes to selective Vasa protein accumulation in multipotent cells during embryogenesis.
Dev Biol. 2011 Jan 15;349(2):440-50. doi: 10.1016/j.ydbio.2010.10.031. Epub 2010 Oct 28.
5
Piwi expression in archeocytes and choanocytes in demosponges: insights into the stem cell system in demosponges.
Evol Dev. 2010 May-Jun;12(3):275-87. doi: 10.1111/j.1525-142X.2010.00413.x.
6
MVH in piRNA processing and gene silencing of retrotransposons.
Genes Dev. 2010 May;24(9):887-92. doi: 10.1101/gad.1902110.
7
Different requirements for conserved post-transcriptional regulators in planarian regeneration and stem cell maintenance.
Dev Biol. 2010 May 15;341(2):429-43. doi: 10.1016/j.ydbio.2010.02.037. Epub 2010 Mar 15.
8
The starlet sea anemone Nematostella vectensis: an anthozoan model organism for studies in comparative genomics and functional evolutionary developmental biology.
Cold Spring Harb Protoc. 2009 Sep;2009(9):pdb.emo129. doi: 10.1101/pdb.emo129.
9
Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors.
Mol Cell Biol. 2010 Apr;30(7):1769-82. doi: 10.1128/MCB.01100-09. Epub 2010 Feb 1.
10
Identifying the germline in an equally cleaving mollusc: Vasa and Nanos expression during embryonic and larval development of the vetigastropod Haliotis asinina.
J Exp Zool B Mol Dev Evol. 2010 Jun 15;314(4):267-79. doi: 10.1002/jez.b.21336.
Zotero 插件