Clinical and Molecular Epidemiology of Cancer Unit, Institut Municipal d'Investigació Mèdica, Universitat Autònoma de Barcelona, Carrer del Dr Aiguader 88, E-08003 Barcelona, Catalonia, Spain.
Occup Environ Med. 2011 May;68(5):332-8. doi: 10.1136/oem.2009.054197. Epub 2010 Nov 23.
Previous studies investigating associations between occupational history and risk of exocrine pancreatic cancer (EPC) did not use biomarkers of exposure. The only two studies that measured internal concentrations of organochlorine compounds (OCs) in EPC did not analyse their relationship with occupation.
To analyse the relationship between occupational history and blood concentrations of seven OCs in patients with EPC.
Incident cases of EPC were prospectively identified, and during hospital admission were interviewed face-to-face on occupational history and life-style factors (n = 135). Occupations were coded according to the International Standard of Occupations 1988. Some occupational exposures were also assessed with the Finnish job-exposure matrix (Finjem). Serum concentrations of OCs were analysed by high-resolution gas chromatography with electron-capture detection.
Craftsmen and related trades workers had significantly higher concentrations of polychlorinated biphenyl (PCB) congeners 138, 153 and 180. Years worked in agriculture did not influence concentrations of p,p'-DDT, p,p'-DDE, hexachlorobenzene or β-hexachlorocyclohexane. Subjects who ever worked in agriculture had lower concentrations of PCBs (all p < 0.05). Occupational exposure to lead, nickel and low frequency magnetic fields was significantly associated with higher concentrations of PCBs.
Certain occupations were associated with higher concentrations of PCBs, suggesting that these compounds may account for some increased risks found in previous studies. The lack of association between work in agriculture and concentrations of OC pesticides is consistent with occupation playing a lesser role than diet in influencing OC concentrations. Occupational studies on the relationships among exposure to industrial agents and EPC risk may need to consider adjusting for exposure to PCBs.
既往研究职业史与外分泌胰腺肿瘤（EPC）风险之间的关联时，并未使用暴露生物标志物。仅有的两项检测 EPC 中有机氯化合物（OCs）内浓度的研究并未分析其与职业的关系。
分析职业史与 EPC 患者血液中 7 种 OCs 浓度之间的关系。
前瞻性识别 EPC 病例，患者住院期间进行面对面访谈，调查职业史和生活方式因素（n=135）。职业按照 1988 年国际标准职业分类编码。某些职业暴露也采用芬兰职业暴露矩阵（Finjem）进行评估。OCs 血清浓度通过高分辨气相色谱-电子捕获检测法分析。
工匠和相关行业工人多氯联苯（PCB）同系物 138、153 和 180 的浓度明显更高。农业工作年限并未影响对，p,p'-DDT、p,p'-DDE、六氯苯或β-六氯环己烷的浓度。曾经从事农业工作的人群 PCB 浓度较低（均 p<0.05）。职业性接触铅、镍和低频磁场与 PCB 浓度升高显著相关。
某些职业与更高浓度的 PCBs 相关，提示这些化合物可能部分解释了既往研究中发现的某些风险增加。农业工作与 OC 农药浓度之间缺乏关联，这与饮食在影响 OC 浓度方面的作用比职业更大一致。关于工业接触与 EPC 风险之间关系的职业研究可能需要考虑调整 PCB 暴露。
