Department of Pharmacology, Medical University of Silesia, Katowice, Jagiellońska 4, PL41-200 Sosnowiec, Poland.
Pharmacol Rep. 2010 Sep-Oct;62(5):900-9. doi: 10.1016/s1734-1140(10)70350-9.
There is increasing interest in the discovery of natural compounds that could favorably affect the skeletal system. Curcumin is a constituent of turmeric, a plant which has been used for centuries as a dietary spice and a traditional Indian medicine. Curcumin has been reported to affect differentiation, activity and the lifespan of osteoblasts and osteoclasts in vitro. The aim of the present study was to investigate the effects of curcumin on the skeletal system of rats in vivo. Curcumin (10 mg/kg, po daily) was administered for four weeks to normal (non-ovariectomized) and bilaterally ovariectomized (estrogen-deficient) three-month-old female Wistar Cmd:(WI)WU rats. Ovariectomy was performed seven days before the start of curcumin administration. Bone mass, mineral and calcium content, macrometric and histomorphometric parameters, as well as the mechanical properties of the bone, were examined. Serum total cholesterol and estradiol levels were also determined. In rats with normal estrogen levels, curcumin decreased serum estradiol level and slightly increased cancellous bone formation, along with decreased mineralization. Estrogen deficiency induced osteoporotic changes in the skeletal system of the ovariectomized control rats. In ovariectomized rats, curcumin decreased body mass gain and serum total cholesterol level, slightly improved some bone histomorphometric parameters impaired by estrogen deficiency, but did not improve bone mineralization or mechanical properties. In conclusion, the results of the present in vivo study in rats did not support the hypothesis that curcumin, at doses that are readily achievable through dietary intake, could be useful for the prevention or treatment of osteoporosis.
人们越来越关注发现能够有益于骨骼系统的天然化合物。姜黄素是姜黄的一种成分，姜黄作为一种食用香料和传统的印度药物，已经使用了几个世纪。据报道，姜黄素可以影响体外成骨细胞和破骨细胞的分化、活性和寿命。本研究的目的是研究姜黄素对体内大鼠骨骼系统的影响。姜黄素（10mg/kg，po 每日）连续 4 周给予正常（未卵巢切除）和双侧卵巢切除（雌激素缺乏）的 3 月龄雌性 Wistar Cmd：（WI）WU 大鼠。卵巢切除术在姜黄素给药前 7 天进行。检测骨量、矿物质和钙含量、宏观和组织形态计量学参数以及骨的机械性能。还测定了血清总胆固醇和雌二醇水平。在雌激素水平正常的大鼠中，姜黄素降低了血清雌二醇水平，略微增加了松质骨形成，同时降低了矿化。雌激素缺乏导致去卵巢对照组大鼠骨骼系统发生骨质疏松变化。在去卵巢大鼠中，姜黄素减少了体重增加和血清总胆固醇水平，略微改善了一些因雌激素缺乏而受损的骨组织形态计量学参数，但没有改善骨矿化或机械性能。总之，本体内研究结果不支持姜黄素在膳食摄入可达到的剂量下可用于预防或治疗骨质疏松症的假说。
