Department of Occupational and Environmental Medicine, Ajou University School of Medicine, Suwon, Korea.
Circ J. 2011;75(1):135-40. doi: 10.1253/circj.cj-09-0948. Epub 2010 Nov 16.
There are limited studies conducted in Asia to investigate the progression rate to hypertension (HTN). This study was done to estimate the progression rate of new-onset pre-HTN (PreHTN) to HTN during an 8-year follow-up period, and to compare the impact of PreHTN on progression to HTN.
A total of 49,228 participants, aged 30 to 54 years with new-onset PreHTN at baseline (1994-1996) from a biennial national medical exam were enrolled and followed up every 2 years until 2004. The incidence rate recorded at each interval and the cumulative incidence rate of HTN were analyzed. Hazard ratio of high-normal and high blood pressure (BP) in men and women was calculated. The cumulative incidence rate for high-normal BP was 27.6% and 26.4% at 2-year follow-up, increased to respectively 64.1% and 55.8% in men and women at the 8-year follow-up. Compared to optimal BP, hazard ratios for men with high-normal BP across all age groups were 3- to 4-fold higher at 2-year, and 2- to 3-fold higher at 8-year follow-up. Hazard ratios for women were about 6-fold higher at 2-year and around 4-fold higher at 8-year follow-up.
New PreHTN was a significant predisposing factor for future HTN, in young adults and the effect is more prominent in women.
亚洲开展的研究有限，无法充分调查高血压（HTN）的进展速度。本研究旨在估计新发生的高血压前期（PreHTN）在 8 年随访期间进展为 HTN 的速度，并比较 PreHTN 对进展为 HTN 的影响。
共有 49228 名参与者，年龄在 30 至 54 岁之间，在基线（1994-1996 年）时患有新发生的 PreHTN，来自每两年进行一次的全国医学检查，随访至 2004 年。分析了每个时间间隔记录的发病率和 HTN 的累积发病率。计算了男性和女性高正常血压和高血压的危险比。高正常血压的累积发病率在 2 年随访时分别为男性和女性的 27.6%和 26.4%，在 8 年随访时分别增加至 64.1%和 55.8%。与最佳血压相比，所有年龄组男性的高正常血压的危险比在 2 年时为 3 至 4 倍，在 8 年时为 2 至 3 倍。女性在 2 年时的危险比约为 6 倍，在 8 年时约为 4 倍。
新的 PreHTN 是未来 HTN 的重要危险因素，在年轻人中更为明显，女性的影响更为显著。
