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[1例因英夫利昔单抗治疗克罗恩病诱发银屑病的病例]

[A case of psoriasis induced by infliximab treatment for Crohn's disease].

作者信息

Jwa Yoon Jung, Kim Nam Hoon, Park Hai Jin, Park Jun Sup, Bae Won Ki, Kim Kyung Ah, Lee June Sung, Moon Young Soo

机构信息

Department of Internal Medicine, lsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.

出版信息

Korean J Gastroenterol. 2010 Nov;56(5):324-8. doi: 10.4166/kjg.2010.56.5.324.

Abstract

Infliximab, the monoclonal antibody to tumor necrosis factor, is indicated for refractory luminal and fistulizing Crohn's disease and rheumatoid arthritis. Infliximab treatment has adverse events including infusion reactions, opportunistic infections, and the potential for the event such as reactivation of latent tuberculosis. Cutaneous adverse reactions of TNF-α agents include skin rash, urticaria, pruritus, lupus-like eruption, and injection site reactions. Most of all, psoriasis or psoriasiform dermatitis induced by infliximab treatment for Crohn's disease is rarely reported in Korea. We report a case of psoriasis induced by infliximab treatment for Crohn's disease with a review of world literature.

摘要

英夫利昔单抗是一种肿瘤坏死因子单克隆抗体,适用于难治性腔外型和瘘管型克罗恩病以及类风湿性关节炎。英夫利昔单抗治疗存在不良事件,包括输液反应、机会性感染以及潜在的如潜伏性结核再激活等情况。肿瘤坏死因子-α制剂的皮肤不良反应包括皮疹、荨麻疹、瘙痒、狼疮样皮疹以及注射部位反应。最重要的是,在韩国,英夫利昔单抗治疗克罗恩病诱发银屑病或银屑病样皮炎的情况鲜有报道。我们报告一例英夫利昔单抗治疗克罗恩病诱发银屑病的病例,并对世界文献进行综述。

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