Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Autophagy. 2011 Jun;7(6):565-71. doi: 10.4161/auto.7.6.14073. Epub 2011 Jun 1.
p53 as a tumor suppressor protein has been implicated in multiple aspects of biological processes, including apoptosis, cell cycle arrest, senescence, metabolism, differentiation and angiogenesis. Recently, several studies have shown that p53 can induce autophagy in both transcription-dependent and -independent manners. Nonetheless, p53 may also inhibit autophagy. In addition, p53 participates in homeostatic regulation of energy metabolism, oxidative stress and amino acid metabolism. Although the relationship between autophagy and p53 is quite complicated, and has not been well elucidated, p53 may underlie key aspects of metabolism and cancer biology. Thus, understanding the novel functions of p53 may allow us to develop new anticancer therapeutic approaches.
p53 作为一种肿瘤抑制蛋白，参与了多个生物学过程，包括细胞凋亡、细胞周期阻滞、衰老、代谢、分化和血管生成。最近的几项研究表明，p53 可以通过转录依赖和非依赖的方式诱导自噬。尽管如此，p53 也可能抑制自噬。此外，p53 参与能量代谢、氧化应激和氨基酸代谢的体内平衡调节。虽然自噬和 p53 之间的关系非常复杂，尚未得到充分阐明，但 p53 可能是代谢和癌症生物学的关键方面的基础。因此，了解 p53 的新功能可能使我们能够开发新的抗癌治疗方法。
