Levine Beth, Abrams John
Nat Cell Biol. 2008 Jun;10(6):637-9. doi: 10.1038/ncb0608-637.
The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.
自噬途径在适应营养应激和肿瘤抑制中发挥作用。p53肿瘤抑制因子以前被认为能正向调节自噬，现在也可能抑制自噬。p53与自噬调节之间的这种双重相互作用令人费解，但可能是新陈代谢和癌症生物学关键方面的基础。
