CNRS EAC, Université Denis Diderot, Paris, France.
Islets. 2010 Mar-Apr;2(2):124-6. doi: 10.4161/isl.2.2.10945.
The concept of functional heterogeneity among β-cells proposes that each cell differs in its sensitivity to glucose and is recruited in a glucose-dependent manner into both biosynthetic and secretory active states in order to adapt insulin secretion to the metabolic environment. Therefore, characterization of β-cell populations with different metabolic sensitivities would lead to the development of new therapeutic strategies. Based on heterogeneous surface PSA-NCAM expression on β-cells, we have recently characterized two groups of cells, namely β(high) and β(low)-cells, in rat. Differences in insulin secretory capacity and in gene expression profiles suggest that β(low)-cells are immature and/or non-functional cells in contrast to highly glucose responsive fully functional β(high)-cells. Moreover, the relative distribution of β(high) and β(low)-cells correlated with physiological and pathological states regarding the functional β-cell mass. Here we summarize our main results on β(high) and β(low)-cell populations and discuss some of the open remaining questions.
β 细胞功能异质性的概念表明，每个细胞对葡萄糖的敏感性不同，并以葡萄糖依赖的方式被募集到合成和分泌活性状态，以适应代谢环境中的胰岛素分泌。因此，对具有不同代谢敏感性的β 细胞群体进行特征描述将导致新的治疗策略的发展。基于β 细胞表面 PSA-NCAM 表达的异质性，我们最近在大鼠中描述了两类细胞，即β(高)和β(低)-细胞。胰岛素分泌能力和基因表达谱的差异表明，β(低)-细胞是不成熟和/或无功能的细胞，而高度葡萄糖反应的功能齐全的β(高)-细胞则不是。此外，β(高)和β(低)-细胞的相对分布与功能β-细胞质量的生理和病理状态相关。在这里，我们总结了我们关于β(高)和β(低)-细胞群体的主要结果，并讨论了一些尚未解决的问题。
