成纤维细胞生长因子 21 增强了同种异体胰岛移植模型中的胰岛移植物的植入。
FGF-21 enhances islet engraftment in mouse syngeneic islet transplantation model.
机构信息
Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.
出版信息
Islets. 2010 Jul-Aug;2(4):247-51. doi: 10.4161/isl.2.4.12402.
Abstract
To clarify the effect of fibroblast growth factor-21 (FGF-21) on islet transplantation, a suboptimal number of islets were transplanted into streptozotocin (STZ)-induced diabetic mice with or without FGF-21 treatment. Three-day treatment with FGF-21 contributed to restoration of normoglycemia by suppressing islet graft loss. The FGF-21-treated mice showed lower glycemic levels despite similar insulin content in the graft than that in untreated mice on day 3, indicating that FGF-21 not only has a cytoprotective effect but also decreases β-cell load by increasing insulin sensitivity. These results suggest that FGF-21 may be useful as a treatment to improve islet engraftment rates in clinical islet transplantation.
摘要
为了阐明成纤维细胞生长因子 21（FGF-21）对胰岛移植的影响，将数量不足的胰岛移植到链脲佐菌素（STZ）诱导的糖尿病小鼠中，并进行或不进行 FGF-21 治疗。FGF-21 治疗 3 天有助于通过抑制胰岛移植物丢失来恢复正常血糖。与未治疗的小鼠相比，FGF-21 治疗的小鼠在第 3 天的移植物中胰岛素含量相似，但血糖水平较低，这表明 FGF-21 不仅具有细胞保护作用，而且通过增加胰岛素敏感性来降低β细胞负荷。这些结果表明，FGF-21 可能可作为改善临床胰岛移植中胰岛移植物植入率的治疗方法。
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