Centre for Paediatrics and Adolescent Medicine, University Medical Centre of the Johannes Guetenberg-University, Mainz, Germany.
Islets. 2010 Sep-Oct;2(5):337-8. doi: 10.4161/isl.2.5.13140. Epub 2010 Sep 1.
Insulin secretion in β-pancreatic cells after glucose stimulation requires the concerted action of a number of different ion channels. The main players seem to be the ATP sensitive K(+) (KATP-) channels, and voltage gated ion channels that drive Ca(2+) influx into β-cells. Recently two calcium activated nonselective (CAN) cation channels (TRPM4 and TRPM5) have been shown to influence efficient insulin response upon glucose stimulation. This addendum summarizes the data known for these two TRP channels in β-cells, discusses some of the remaining open questions and addresses a possible scenario that involves and integrates the triggering and amplifying pathway of glucose mediated insulin secretion.
β-胰腺细胞在葡萄糖刺激后的胰岛素分泌需要多种不同离子通道的协同作用。主要参与者似乎是 ATP 敏感的钾（KATP-）通道，以及驱动 Ca2+流入β细胞的电压门控离子通道。最近，两种钙激活非选择性（CAN）阳离子通道（TRPM4 和 TRPM5）已被证明会影响葡萄糖刺激时的有效胰岛素反应。本文增刊总结了这两种 TRP 通道在 β 细胞中的已知数据，讨论了一些悬而未决的问题，并提出了一种可能的情况，涉及并整合了葡萄糖介导的胰岛素分泌的触发和放大途径。
