一种 TRP 通道参与了胰岛β细胞的胰岛素分泌。
A TRP channel contributes to insulin secretion by pancreatic β-cells.
机构信息
Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA, USA.
出版信息
Islets. 2010 Sep-Oct;2(5):331-3. doi: 10.4161/isl.2.5.12973. Epub 2010 Sep 1.
Abstract
The release of insulin by pancreatic beta cells involves a complex interplay of conductances that generate oscillations and drive secretion. A recent report identifies a new player in this process, the ion channel TRPM5. TRPM5 was originally identified in taste cells, where it forms a Ca(2+)-activated cation channel that is required for sensory responses to bitter and sweet tastes. New research now shows that TRPM5 is expressed within the pancreatic islets of Langerhans, where it regulates the frequency of Ca(2+) oscillations and contributes to insulin release by β-cells.
摘要
胰腺β细胞分泌胰岛素涉及一系列复杂的电导活动，这些活动产生振荡并驱动分泌。最近的一份报告确定了这一过程中的一个新参与者，即离子通道 TRPM5。TRPM5 最初在味觉细胞中被发现，在那里它形成一个 Ca(2+)-激活的阳离子通道，是对苦味和甜味的感觉反应所必需的。新的研究现在表明，TRPM5 在胰岛内表达，调节 Ca(2+)振荡的频率，并通过β细胞促进胰岛素的释放。
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本文引用的文献
1
TRPM5 regulates glucose-stimulated insulin secretion.
Pflugers Arch. 2010 Jun;460(1):69-76. doi: 10.1007/s00424-010-0835-z.
2
Electrical bursting, calcium oscillations, and synchronization of pancreatic islets.
Adv Exp Med Biol. 2010;654:261-79. doi: 10.1007/978-90-481-3271-3_12.
3
Calcium signaling in the islets.
Adv Exp Med Biol. 2010;654:235-59. doi: 10.1007/978-90-481-3271-3_11.
4
Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice.
Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5208-13. doi: 10.1073/pnas.0913107107. Epub 2010 Mar 1.
5
Intracellular calcium activates TRPM2 and its alternative spliced isoforms.
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7239-44. doi: 10.1073/pnas.0811725106. Epub 2009 Apr 16.
6
Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate.
J Gen Physiol. 2009 Feb;133(2):189-203. doi: 10.1085/jgp.200810109.
7
TRPM5-expressing microvillous cells in the main olfactory epithelium.
BMC Neurosci. 2008 Nov 24;9:114. doi: 10.1186/1471-2202-9-114.
8
TRPM5-expressing solitary chemosensory cells respond to odorous irritants.
J Neurophysiol. 2008 Mar;99(3):1451-60. doi: 10.1152/jn.01195.2007. Epub 2007 Dec 26.
9
The transduction channel TRPM5 is gated by intracellular calcium in taste cells.
J Neurosci. 2007 May 23;27(21):5777-86. doi: 10.1523/JNEUROSCI.4973-06.2007.
10
Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4.
Nat Immunol. 2007 Mar;8(3):312-20. doi: 10.1038/ni1441. Epub 2007 Feb 11.
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