Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA.
Pediatr Infect Dis J. 2011 May;30(5):379-83. doi: 10.1097/INF.0b013e318202ac3a.
Ureaplasma respiratory tract colonization is associated with bronchopulmonary dysplasia (BPD) in preterm infants. Whether the 4 Ureaplasma parvum and 10 Ureaplasma urealyticum serovars differ in virulence is unknown. This study was conducted to determine the distribution of Ureaplasma serovars in respiratory secretions of a prospective cohort of preterm infants and to assess whether any of the serovars are associated with BPD.
Serial endotracheal and/or nasopharyngeal aspirates were obtained for Ureaplasma culture and PCR from 136 infants of gestational age <33 weeks. All positive samples were speciated and serovars were determined by real-time PCR.
A total of 51 (37.5%) infants were Ureaplasma-positive one or more times during the first month of life. Respiratory colonization was inversely related to gestational age. Sixty-five percent of infants <26 weeks compared with 31% infants ≥ 26 weeks were culture or PCR positive. U. parvum was more common (N = 32, 63%) than U. urealyticum (N = 17, 33%); both species were present in 2 samples. Serovars 3 and 6 alone and in combination accounted for 96% U. parvum isolates. U. urealyticum isolates were commonly a mixture of multiple serovars, with serovar 11 alone or combined with other serovars (10/17, 59%) being the most common serovar. No individual species or serovars or serovar mixtures were associated with moderate-to-severe BPD.
U. parvum serovars 3 and 6 and U. urealyticum serovar 11 were the most common serovars detected in respiratory samples from a prospective cohort of preterm infants.
解脲脲原体呼吸道定植与早产儿支气管肺发育不良（BPD）有关。脲原体细小脲原体和 10 种解脲脲原体血清型在毒力上是否存在差异尚不清楚。本研究旨在确定前瞻性早产儿队列呼吸道分泌物中脲原体血清型的分布，并评估是否存在与 BPD 相关的血清型。
对 136 名胎龄<33 周的婴儿进行了连续的气管内和/或鼻咽抽吸，以进行 Ureaplasma 培养和 PCR。所有阳性样本均进行分类，并通过实时 PCR 确定血清型。
共有 51 名（37.5%）婴儿在生命的第一个月内有一次或多次 Ureaplasma 阳性。呼吸道定植与胎龄呈负相关。65%的<26 周婴儿比 31%的≥26 周婴儿培养或 PCR 阳性。Ureaplasma parvum 比 Ureaplasma urealyticum 更为常见（N=32，63%）；两种均存在于 2 个样本中。血清型 3 和 6 单独或组合占 Ureaplasma parvum 分离株的 96%。Ureaplasma urealyticum 分离株通常是多种血清型的混合物，其中血清型 11 单独或与其他血清型（17 个分离株中的 10 个，59%）组合是最常见的血清型。没有发现单独的物种、血清型或血清型混合物与中重度 BPD 相关。
在前瞻性早产儿队列的呼吸道样本中，Ureaplasma parvum 血清型 3 和 6 以及 Ureaplasma urealyticum 血清型 11 是最常见的血清型。
