Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, No. 20, Section 3, Renmin Road South, Chengdu, Sichuan, 610041, P. R. China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, China.
BMC Infect Dis. 2024 Aug 21;24(1):849. doi: 10.1186/s12879-024-09760-9.
The aim of this study was to investigate the epidemiological characteristics and antibiotic resistance patterns of Ureaplasma urealyticum (UU) infection among women and children in southwest China.
A total of 8,934 specimens, including urogenital swabs and throat swabs were analyzed in this study. All samples were tested using RNA-based Simultaneous Amplification and Testing (SAT) methods. Culture and drug susceptibility tests were performed on UU positive patients.
Among the 8,934 patients, the overall positive rate for UU was 47.92%, with a higher prevalence observed among women of reproductive age and neonates. The majority of UU positive outpatients were women of reproductive age (88.03%), while the majority of UU positive inpatients were neonates (93.99%). Overall, hospitalization rates due to UU infection were significantly higher in neonates than in women. Further analysis among neonatal inpatients revealed a higher incidence of preterm birth and low birth weight in UU positive inpatients (52.75% and 3.65%, respectively) than in UU negative inpatients (44.64% and 2.89%, respectively), especially in very preterm and extremely preterm neonates. Moreover, the incidence rate of bronchopulmonary dysplasia (BPD) among hospitalized neonatal patients was significantly higher in the UU positive group (6.89%) than in the UU negative group (4.18%). The drug susceptibility tests of UU in the neonatology, gynecology and obstetrics departments exhibited consistent sensitivity patterns to antibiotics, with high sensitivity to tetracyclines and macrolides, and low sensitivity to fluoroquinolones. Notably, UU samples collected from the neonatology department exhibited significantly higher sensitivity to azithromycin and erythromycin (93.8% and 92.9%, respectively) than those collected from the gynecology and obstetrics departments.
This study enhances our understanding of the current epidemiological characteristics and antibiotic resistance patterns of UU infection among women and children in southwest China. These findings can aid in the development of more effective intervention, prevention and treatment strategies for UU infection.
本研究旨在调查中国西南地区妇女和儿童中解脲脲原体（UU）感染的流行病学特征和抗生素耐药模式。
本研究共分析了 8934 份标本，包括泌尿生殖道拭子和咽拭子。所有样本均采用基于 RNA 的同时扩增和检测（SAT）方法进行检测。对 UU 阳性患者进行培养和药敏试验。
在 8934 例患者中，UU 的总阳性率为 47.92%，在育龄妇女和新生儿中更为常见。大多数 UU 阳性门诊患者为育龄妇女（88.03%），而大多数 UU 阳性住院患者为新生儿（93.99%）。总体而言，UU 感染导致的住院率在新生儿中明显高于妇女。对新生儿住院患者的进一步分析显示，UU 阳性患者的早产和低出生体重发生率（分别为 52.75%和 3.65%）高于 UU 阴性患者（分别为 44.64%和 2.89%），尤其是在极早产儿和超早产儿中。此外，住院新生儿患者支气管肺发育不良（BPD）的发生率在 UU 阳性组（6.89%）明显高于 UU 阴性组（4.18%）。新生儿科、妇产科 UU 的药敏试验对抗生素表现出一致的敏感性模式，对四环素类和大环内酯类高度敏感，对氟喹诺酮类敏感性较低。值得注意的是，与妇产科相比，新生儿科采集的 UU 样本对阿奇霉素和红霉素的敏感性显著更高（分别为 93.8%和 92.9%）。
本研究提高了我们对中国西南地区妇女和儿童中 UU 感染当前流行病学特征和抗生素耐药模式的认识。这些发现有助于制定更有效的干预、预防和治疗 UU 感染的策略。
