Woudenberg F, Slangen J L
Netherlands Institute for Drug and Doping Research, Faculty of Pharmacy, University of Utrecht.
Eur J Pharmacol. 1990 Mar 13;178(1):29-36. doi: 10.1016/0014-2999(90)94790-5.
Rats were trained to discriminate flumazenil (15 mg/kg i.p.) from vehicle in a two-lever, food-reinforced, operant conditioning procedure. Substitution tests were performed with a wide dose range of flumazenil and of several benzodiazepines and non-benzodiazepine compounds possessing behavioural effects similar to or opposite to those of benzodiazepine agonists. The results indicate that low doses of flumazenil have behavioural effects, that the flumazenil cue has a low degree of specificity and is most strongly related to the stimulus properties of benzodiazepines.
在两杆、食物强化的操作性条件反射程序中，训练大鼠区分氟马西尼（腹腔注射15毫克/千克）和赋形剂。用广泛剂量范围的氟马西尼以及几种具有与苯二氮䓬激动剂相似或相反行为效应的苯二氮䓬类和非苯二氮䓬类化合物进行替代试验。结果表明，低剂量的氟马西尼具有行为效应，氟马西尼线索的特异性程度较低，且与苯二氮䓬类药物的刺激特性关系最为密切。
