Woudenberg F, Slangen J L
Netherlands Institute for Drugs and Doping Research, Faculty of Pharmacy, University of Utrecht, The Netherlands.
Psychopharmacology (Berl). 1989;97(4):466-70. doi: 10.1007/BF00439549.
Rats (N = 12) were trained to discriminate midazolam (1 mg/kg, IP) from vehicle in a food reinforced operant conditioning procedure. Midazolam, flunitrazepam, diazepam, chlordiazepoxide and pentobarbital showed dose-dependent substitution for midazolam. Buspirone and Ro 15-1788 did not substitute for midazolam. The midazolam cue was dose-dependently antagonized by Ro 15-1788. In rats (N = 12) trained to discriminate chlordiazepoxide (3 mg/kg, IP) from vehicle midazolam, flunitrazepam, diazepam and chlordiazepoxide substituted completely and dose dependently for chlordiazepoxide. The relative potency of chlordiazepoxide and diazepam was three times less in the midazolam-trained animals than in the chlordiazepoxide-trained animals. Response rate and latency data further support the main finding that the midazolam cue is similar, but not identical to the cue of classical benzodiazepines.
在食物强化操作性条件反射程序中，训练12只大鼠区分咪达唑仑（1毫克/千克，腹腔注射）和溶剂。咪达唑仑、氟硝西泮、地西泮、氯氮卓和戊巴比妥对咪达唑仑表现出剂量依赖性替代作用。丁螺环酮和Ro 15-1788不能替代咪达唑仑。Ro 15-1788对咪达唑仑线索有剂量依赖性拮抗作用。在训练区分氯氮卓（3毫克/千克，腹腔注射）和溶剂的12只大鼠中，咪达唑仑、氟硝西泮、地西泮和氯氮卓对氯氮卓完全且剂量依赖性地替代。在接受咪达唑仑训练的动物中，氯氮卓和地西泮的相对效价比在接受氯氮卓训练的动物中低三倍。反应率和潜伏期数据进一步支持了主要发现，即咪达唑仑线索与经典苯二氮卓类药物的线索相似，但不完全相同。
