Meraïhi Z, Lutz O, Scheftel J M, Frey A, Bach A C
Laboratoire de la Clinique Médicale A., Hôpital Civil, Strasbourg, France.
Infection. 1990 Mar-Apr;18(2):109-12. doi: 10.1007/BF01641428.
To study the influence of a gram-positive sepsis on the metabolism of circulating lipids, fasted rats were injected with saline (control group) or with a suspension of heat-killed or live Staphylococcus aureus. 18 h later, body temperature was increased, while albuminemia and ketonemia were decreased in the group injected with heat-killed bacteria, as opposed to the control group. Passing from these groups to the group injected with live bacteria, more differences appeared: increase of triglyceridemia and free cholesterolemia; decrease of esterified cholesterol levels and especially of the in vitro activity of diaphragm, heart and adipose tissue lipoprotein lipase and of hepatic lipase. The decrease of lipolytic activities occurred whether they were measured on a fat emulsion containing long-chain or medium- and long-chain triglycerides. The fact that for the latter the activity was always higher than for the former suggests that the host infected with gram-positive bacteria would clear exogenous fat more easily in the case of medium-chain triglycerides.
为研究革兰氏阳性菌败血症对循环脂质代谢的影响，将禁食大鼠注射生理盐水（对照组）或热灭活或活的金黄色葡萄球菌悬液。18小时后，与对照组相比，注射热灭活菌的组体温升高，而白蛋白血症和酮血症降低。从这些组到注射活菌的组，出现了更多差异：甘油三酯血症和游离胆固醇血症增加；酯化胆固醇水平降低，尤其是膈肌、心脏和脂肪组织脂蛋白脂肪酶以及肝脂肪酶的体外活性降低。无论在含有长链或中长链甘油三酯的脂肪乳剂上测量，脂解活性均降低。对于后者，其活性总是高于前者，这一事实表明，感染革兰氏阳性菌的宿主在使用中链甘油三酯时能更轻松地清除外源性脂肪。
