全胃肠外营养对慢性和急性疾病期间组织脂蛋白脂肪酶活性的影响。
Influence of total parenteral nutrition on tissue lipoprotein lipase activity during chronic and acute illness.
作者信息
Robin A P, Greenwood M R, Askanazi J, Elwyn D H, Kinney J M
出版信息
Ann Surg. 1981 Dec;194(6):681-6. doi: 10.1097/00000658-198112000-00003.
This study examines the influence of total parenteral nutrition (TPN) compared with 5% dextrose (D5) infusion on skeletal muscle and adipose tissue lipoprotein lipase (LPL) activity in nutritionally depleted, injured and infected patients. The plasma concentrations of glucose, free fatty acid (FFA), triglyceride and insulin were also measured. During TPN, nutritionally depleted subjects showed an increase in adipose tissue LPL activity, "fat cell size," and plasma insulin concentration. Skeletal muscle LPL activity and plasma FFA concentration decreased. In comparison, trauma patients showed a less marked rise in adipose tissue LPL activity and skeletal muscle LPL activity increased. Infected patients had a much smaller rise in adipose tissue LPL activity than either of the other groups, and muscle activity rose. The depleted and injured patients showed a linear relationship between adipose tissue LPL activity and plasma insulin concentration and an inverse hyperbolic relationship between adipose tissue LPL activity and plasma FFA concentration.
本研究探讨了全胃肠外营养（TPN）与5%葡萄糖（D5）输注相比，对营养缺乏、受伤及感染患者骨骼肌和脂肪组织脂蛋白脂肪酶（LPL）活性的影响。同时还测定了血浆葡萄糖、游离脂肪酸（FFA）、甘油三酯和胰岛素的浓度。在TPN期间，营养缺乏的受试者脂肪组织LPL活性、“脂肪细胞大小”和血浆胰岛素浓度升高。骨骼肌LPL活性和血浆FFA浓度降低。相比之下，创伤患者脂肪组织LPL活性升高不明显，骨骼肌LPL活性增加。感染患者脂肪组织LPL活性升高幅度远小于其他两组，肌肉活性升高。营养缺乏和受伤患者脂肪组织LPL活性与血浆胰岛素浓度呈线性关系，脂肪组织LPL活性与血浆FFA浓度呈反双曲线关系。
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