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SIRT1：来自小鼠模型的最新研究成果。

SIRT1: recent lessons from mouse models.

机构信息

Tumour Suppression Group, Spanish National Cancer Research Center (CNIO), 3 Melchor Fernandez Almagro Street, Madrid E-28029, Spain.

出版信息

Nat Rev Cancer. 2010 Dec;10(12):819-23. doi: 10.1038/nrc2962. Epub 2010 Nov 24.

DOI:10.1038/nrc2962
PMID:21102633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3672967/
Abstract

The family of protein deacetylases represented by yeast Sir2 has been the focus of intense investigation because of the longevity activity of Sir2 in yeast, worms and flies. Research in mammals has mainly focused on SIRT1, the closest homologue of Sir2. Emerging evidence from mouse models is yielding a sharper picture, in which SIRT1 is a potent protector from ageing-associated pathologies, such as diabetes, liver steatosis, cardiovascular disease, neurodegeneration and, importantly, various types of cancer.

摘要

以酵母 Sir2 为代表的蛋白去乙酰化酶家族一直是研究的焦点，因为 Sir2 在酵母、蠕虫和苍蝇中的长寿活性。哺乳动物的研究主要集中在 SIRT1 上，它是 Sir2 的最接近同源物。来自小鼠模型的新证据提供了更清晰的画面，其中 SIRT1 是一种强大的保护剂，可以预防与衰老相关的病理，如糖尿病、脂肪肝、心血管疾病、神经退行性变，以及重要的各种癌症。

相似文献

[1]
SIRT1: recent lessons from mouse models.

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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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[5]
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[6]
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[7]
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[8]
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本文引用的文献

[1]
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

Nat Commun. 2010-4-12

[2]
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism.

J Biol Chem. 2010-9-3

[3]
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.

Cell Metab. 2010-9-8

[4]
SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus.

J Neurosci. 2010-7-28

[5]
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

Cell. 2010-7-23

[6]
Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress.

Mol Cell Biol. 2010-7-20

[7]
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity.

Cell Metab. 2010-7-7

[8]
SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice.

Aging (Albany NY). 2010-6

[9]
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

Genes Dev. 2010-7-1

[10]
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation.

Cell Metab. 2010-6-9

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