Tumour Suppression Group, Spanish National Cancer Research Center (CNIO), 3 Melchor Fernandez Almagro Street, Madrid E-28029, Spain.
Nat Rev Cancer. 2010 Dec;10(12):819-23. doi: 10.1038/nrc2962. Epub 2010 Nov 24.
The family of protein deacetylases represented by yeast Sir2 has been the focus of intense investigation because of the longevity activity of Sir2 in yeast, worms and flies. Research in mammals has mainly focused on SIRT1, the closest homologue of Sir2. Emerging evidence from mouse models is yielding a sharper picture, in which SIRT1 is a potent protector from ageing-associated pathologies, such as diabetes, liver steatosis, cardiovascular disease, neurodegeneration and, importantly, various types of cancer.
以酵母 Sir2 为代表的蛋白去乙酰化酶家族一直是研究的焦点，因为 Sir2 在酵母、蠕虫和苍蝇中的长寿活性。哺乳动物的研究主要集中在 SIRT1 上，它是 Sir2 的最接近同源物。来自小鼠模型的新证据提供了更清晰的画面，其中 SIRT1 是一种强大的保护剂，可以预防与衰老相关的病理，如糖尿病、脂肪肝、心血管疾病、神经退行性变，以及重要的各种癌症。
