Dunn A K, Smithpeter C, Welch A J, Richards-Kortum R
Appl Opt. 1996 Jul 1;35(19):3441-6. doi: 10.1364/AO.35.003441.
The relationship between optical properties and image contrast in confocal imaging is investigated. A Monte Carlo simulation has been developed to analyze the effects of changes in scattering, index of refraction, and absorption in a three-layer medium. Contrast was calculated from the computed signal-to-background ratios for changes in tissue optical properties. Results show that the largest source of contrast is changes in refractive index.
研究了共聚焦成像中光学特性与图像对比度之间的关系。已开发出一种蒙特卡罗模拟方法，用于分析三层介质中散射、折射率和吸收变化的影响。根据计算出的组织光学特性变化的信号与背景比率来计算对比度。结果表明，对比度的最大来源是折射率的变化。
