Patwardhan Sachin V, Dhawan Atam P, Relue Patricia A
Department of Electrical and Computer Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA.
IEEE Trans Biomed Eng. 2005 Jul;52(7):1227-36. doi: 10.1109/TBME.2005.847546.
Three-dimensional, voxel-based, and wavelength-dependent skin lesion models are developed and simulated using Monte Carlo techniques. The optical geometry of the Nevoscope with trans-illumination is used in the simulations for characterizing the lesion thickness. Based on the correlation analysis between the lesion thickness and the diffuse reflectance, optical wavelengths are selected for multispectral imaging of skin lesions using the Nevoscope. Tissue optical properties reported by various researchers are compiled together to form a voxel library. Tissue models used in the simulations are developed using the voxel library which offers flexibility in updating the optical properties and adding new media types into the models independent of the Monte Carlo simulation code.
利用蒙特卡罗技术开发并模拟了三维、基于体素且与波长相关的皮肤病变模型。模拟中使用具有透照功能的皮肤镜的光学几何结构来表征病变厚度。基于病变厚度与漫反射率之间的相关性分析，选择光学波长用于皮肤，以便使用皮肤镜对皮肤病变进行多光谱成像。将不同研究人员报告的组织光学特性汇总在一起，形成一个体素库。模拟中使用的组织模型是利用该体素库开发的，这使得在更新光学特性以及将新的介质类型添加到模型中时具有灵活性，且与蒙特卡罗模拟代码无关。
