Chan Raymond C K, Gottesman Irving I, Ge Xiaojia, Sham Pak C
Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences Beijing, China.
Front Hum Neurosci. 2010 Oct 28;4:207. doi: 10.3389/fnhum.2010.00207. eCollection 2010.
Endophenotypic research can be considered to be one of the most promising strategies to bridge the gap between genomic complexity and the phenotypic heterogeneity observed in neuropsychiatric disorders. However, despite the promising and systematic work initiated by our western counterparts, this research strategy is still not well known in developing countries. Thus, the purpose of this paper is to argue the merits and promise of a potentially useful database on phenotypes and endophenotypes for developing countries.
内表型研究可被视为弥合神经精神疾病中基因组复杂性与所观察到的表型异质性之间差距的最具前景的策略之一。然而，尽管我们的西方同行开展了有前景且系统的工作，但这种研究策略在发展中国家仍不太为人所知。因此，本文的目的是论证一个对发展中国家可能有用的关于表型和内表型的数据库的优点和前景。
