Hoskins D D, Brandt H, Acott T S
Fed Proc. 1978 Sep;37(11):2534-42.
Spermatozoa acquire the capacity for motility as they traverse the mammalian epididymis. The biochemical basis for this induction of motility is still largely unknown. Current theories are discussed and recent studies from the authors' laboratory are described which indicate that two separate processes are involved and that these act synergistically. These processes are an increase in the intrasperm content of cyclic AMP during epididymal transit combined with the binding of a specific forward-motility protein. A second increase in cyclic AMP and stimulation by calcium ion is likely involved in the expression of the acquired potential for motility at the time of ejaculation.
精子在穿过哺乳动物附睾的过程中获得运动能力。这种运动能力诱导的生化基础在很大程度上仍然未知。本文讨论了当前的理论，并描述了作者实验室的最新研究，这些研究表明涉及两个独立的过程，且它们协同作用。这些过程是在附睾转运过程中精子内环状AMP含量的增加，以及一种特定的向前运动蛋白的结合。射精时，环状AMP的再次增加和钙离子的刺激可能参与了所获得的运动潜能的表达。
