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Engineering peptide inhibitors to overcome PDZ binding promiscuity.

作者信息

Vouilleme Lars, Cushing Patrick R, Volkmer Rudolf, Madden Dean R, Boisguerin Prisca

机构信息

Institute of Medical Immunology, Charité-Universitätsmedizin Berlin, Hessische Strasse 3-4, 10115 Berlin, Germany.

出版信息

Angew Chem Int Ed Engl. 2010 Dec 17;49(51):9912-6. doi: 10.1002/anie.201005575.

Abstract
摘要

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本文引用的文献

1
A stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR.
Angew Chem Int Ed Engl. 2010 Dec 17;49(51):9907-11. doi: 10.1002/anie.201005585.
2
Synthesis and application of peptide arrays: quo vadis SPOT technology.
Chembiochem. 2009 Jun 15;10(9):1431-42. doi: 10.1002/cbic.200900078.
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Design of protein-interaction specificity gives selective bZIP-binding peptides.
Nature. 2009 Apr 16;458(7240):859-64. doi: 10.1038/nature07885.
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A specificity map for the PDZ domain family.
PLoS Biol. 2008 Sep 30;6(9):e239. doi: 10.1371/journal.pbio.0060239.
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The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recycling.
Biochemistry. 2008 Sep 23;47(38):10084-98. doi: 10.1021/bi8003928. Epub 2008 Aug 29.
7
Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains.
Bioorg Med Chem Lett. 2008 Feb 1;18(3):942-5. doi: 10.1016/j.bmcl.2007.12.038. Epub 2007 Dec 23.
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PDZ domain binding selectivity is optimized across the mouse proteome.
Science. 2007 Jul 20;317(5836):364-9. doi: 10.1126/science.1144592.
10
NHE3 inhibits PKA-dependent functional expression of CFTR by NHERF2 PDZ interactions.
Biochem Biophys Res Commun. 2006 Aug 25;347(2):452-9. doi: 10.1016/j.bbrc.2006.06.112. Epub 2006 Jun 28.

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